Abstract
The synthesis and the SAR study of novel O-substituted 8-quinolines and 4-benzothiazoles as highly potent non-peptide bradykinin B2 receptor antagonists are described. Several members of this series of antagonists efficiently inhibited the BK-induced vasoconstriction on different isolated organ preparations.
MeSH terms
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Benzothiazoles
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Bradykinin Receptor Antagonists*
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Quinolines / chemical synthesis
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Quinolines / chemistry
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Quinolines / pharmacology*
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Receptor, Bradykinin B2
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Structure-Activity Relationship
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Thiazoles / chemical synthesis
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Thiazoles / chemistry
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Thiazoles / pharmacology*
Substances
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Benzothiazoles
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Bradykinin Receptor Antagonists
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Quinolines
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Receptor, Bradykinin B2
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Thiazoles
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benzothiazole